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EL

Dr. Lee

Endocrinology

Dose Review: Alex Rivera

Week 2 escalation · Check-in received

Ready to approve — Alex Rivera passed all safety checks

Propose: 3 mg · 30 units·+0.5 mg from 2.5 mg current

Dose Escalation Comparison

Standard protocol vs. First Dose Health micro-titration

Alex Rivera · Week 2

Standard Protocol

Large monthly jumps — higher GI risk

1
2.5 mg
Wk 1–4
+2.5 mg jump
2
5.0 mg
Wk 5–8
+2.5 mg jump
3
7.5 mg
Wk 9–12
+2.5 mg jump
4
10.0 mg
Wk 13+
Each jump doubles the dose — common cause of nausea and discontinuation

First Dose Health Micro-Titration

Gradual 0.5 mg weekly steps — guided by symptoms

1
2.5 mg
Week 1
+0.5 mg only
2
3.0 mgPROPOSED
Week 2
+0.5 mg only
3
3.5 mg
Week 3
+0.5 mg only
4
4.0 mg
Week 4
+0.5 mg only
5
4.5 mg
Week 5
6
Hold or continue
Week 6+
Goal: find the lowest effective dose, not the maximum tolerated dose

Patient Response

Week 1 Symptom Summary

Nausea

0/3

None

Reflux

0/3

None

Dizziness

0/3

None

Constipation

0/3

None

Recommendation: Safe to escalate

All symptom scores ≤ 1/3. No contraindications. Weight loss on track at −2.2 lbs.

Safety Rules

Max symptom score < 2 for all categories

Highest: Nausea 1/3

No new onset of severe symptoms

No severe symptoms

Weight change within expected range

−2.2 lbs (expected: −1 to −4 lbs)

Patient completed check-in on time

Submitted Day 7

No orthostatic symptoms

Dizziness: 0/3

Audit Trail

Complete clinical activity log

System·10:32 AM

Intake form received from Alex Rivera

System·10:32 AM

Risk assessment generated: 3 flags identified

System·10:33 AM

Micro-titration plan drafted: 2.5 mg start, 0.5 mg weekly steps

Dr. Kim·10:45 AM

Reviewed plan, approved Week 1 dose (2.5 mg / 25 units)

Alex Rivera·Day 7

Completed injection and symptom check-in

System·Day 7

Symptom analysis: Nausea mild (1/3), all others 0. Safe to escalate.

System·Day 7

Proposed Week 2 dose: 3.0 mg / 30 units -- awaiting clinician review